Citicoline Side Effects

Citicoline, also known as CDP-choline, is a popular dietary supplement that is used to enhance cognitive function and memory. It is derived from choline, which is a nutrient that is found in some foods and is important for the brain and nervous system. While Citicoline is generally considered safe, there are some potential side effects that users should be aware of. In this article, we will explore the benefits of Citicoline and its potential side effects.

How Citicoline Works

Citicoline works by increasing the availability of choline and cytidine, which are used in the synthesis of neurotransmitters and phospholipids, and nucleic acids, respectively. 

Specifically, choline is predominantly used in the brain to make acetylcholine, which is the most important neurotransmitter for executive cognitive function. More acetylcholine essentially means more raw processing power, faster reaction times, better mind-muscle connection, and better working memory. 

Phospholipids are essential components of cell membranes and are important for the normal functioning of cells in the brain and nervous system. Cytidine is a precursor to uridine, which is another important component of cell membranes.

Citicoline has been shown to enhance cognitive function and memory in a number of clinical studies. It has also been shown to improve brain metabolism and blood flow, and to have neuroprotective effects.

Citicoline Side Effects

While Citicoline is generally considered safe, there are some potential side effects that users should be aware of. These include:

  • Headaches: Citicoline can sometimes cause headaches, particularly at higher doses. This is because Citicoline increases levels of acetylcholine in the brain, which can sometimes cause headaches.
  • Nausea: Some users of Citicoline may experience nausea, particularly if they take it on an empty stomach. This is because Citicoline can cause an increase in stomach acid.
  • Insomnia: Citicoline can sometimes cause insomnia or difficulty sleeping. This is because Citicoline increases levels of acetylcholine in the brain, which can sometimes cause wakefulness.
  • Restlessness: Some users of Citicoline may experience restlessness or jitteriness. This is because Citicoline can cause an increase in the levels of dopamine in the brain.
  • Diarrhea: Citicoline can sometimes cause diarrhea or loose stools. This is because Citicoline can cause an increase in stomach acid, which can lead to digestive upset.

While these side effects are generally mild and temporary, users should still be aware of them and monitor their symptoms carefully. If any of these side effects persist or worsen, users should consult their healthcare provider.

Should I take Citicoline every day?

citicoline side effects woman

Yes, Citicoline is most effective when taken on a daily basis. Citicoline is a natural compound that is essential for the health and function of brain cells. It plays a critical role in the synthesis of phosphatidylcholine, a component of the brain cell membrane, and acetylcholine, a neurotransmitter that is involved in memory and learning.

Studies have shown that daily use of Citicoline can improve cognitive function,  memory, and attention span. In addition, Citicoline has been shown to have neuroprotective effects and may help to reduce the risk of age-related cognitive decline. Nootropics for ADD and ADHD often contain Citicoline. 

Citicoline is a safe and well-tolerated dietary supplement that can be taken daily to provide maximum benefits. It is important to start with a low dose and gradually increase over time to determine the optimal dosage for each individual. As with any dietary supplement, it is important to consult with a healthcare professional before beginning use.

Citicoline Side Effect FAQs

What are the contraindications of citicoline?

Citicoline is generally considered safe for most people. However, there are some people who should not take Citicoline or who should consult with their healthcare provider before taking it. These include people who have a history of bipolar disorder or who are currently taking medication for bipolar disorder.

Can citicoline raise blood pressure?

There is some evidence to suggest that Citicoline may have a slight effect on blood pressure. However, this effect is generally considered to be small and is unlikely to cause any significant problems for most users.

How does citicoline make you feel?

Citicoline is generally considered to have a positive effect on mood and cognitive function. Many users report feeling more alert, focused, and mentally sharp when taking Citicoline.

Does citicoline have long term side effects?

There is no evidence to suggest that Citicoline has any long-term side effects. However, more research is needed to fully understand the long-term effects of Citicoline use.

Conclusion: Is Citicoline Safe?

Despite the potential side effects, Citicoline is generally considered to be safe and well-tolerated by most people. In fact, Citicoline is classified as a Generally Recognized As Safe (GRAS) substance by the U.S. Food and Drug Administration (FDA). This means that Citicoline has a long history of safe use in foods and supplements.

Citicoline is also considered to be safe for use in most medical conditions. However, people who have a history of bipolar disorder or who are currently taking medication for bipolar disorder should consult with their healthcare provider before taking Citicoline. This is because Citicoline can increase levels of dopamine in the brain, which can sometimes trigger manic episodes in people with bipolar disorder.

In addition to its cognitive benefits, Citicoline has been shown to have neuroprotective effects. It has been studied for its potential to help prevent and treat a variety of neurological conditions, including stroke, traumatic brain injury, and Alzheimer's disease. Citicoline has also been shown to improve recovery and outcomes in patients who have suffered from a traumatic brain injury.

In conclusion, Citicoline is a safe and effective dietary supplement that can help enhance cognitive function and memory. While there are some potential side effects associated with Citicoline use, these are generally mild and temporary. People who are considering taking Citicoline should consult with their healthcare provider to ensure that it is safe for them to do so.

Stacking Citicoline: How to safely get the most out of the nootropic


While Citicoline is generally safe and well-tolerated on its own, many people choose to stack it with other nootropic supplements to enhance its effects.

One popular nootropic stack that includes Citicoline is a combination of Citicoline, tyrosine, and caffeine. This stack can provide a synergistic effect that enhances cognitive function, improves mood, and increases energy levels.

Tyrosine is an amino acid that is a precursor to dopamine, a neurotransmitter that is associated with motivation, mood, and focus. When taken with Citicoline, tyrosine can help to enhance the cognitive benefits of Citicoline and improve motivation and mood.

Caffeine is a stimulant that can increase energy levels and improve focus. When combined with Citicoline and tyrosine, caffeine can provide an extra boost of energy and focus, making it an ideal addition to this nootropic stack.

It is important to note that when stacking nootropics, it is essential to start with low doses and gradually increase over time to determine the optimal dosage for each individual. It is also important to be aware of potential side effects and to monitor any changes in mood, energy, or cognitive function.

Overall, the combination of Citicoline, tyrosine, and caffeine can be a powerful nootropic stack that can enhance cognitive function, improve mood, and increase energy levels. As with any dietary supplement or nootropic stack, it is important to consult with a healthcare professional before beginning use.

Choose the Vyvamind package that’s right for you

Note: Some of Vyvamind’s benefits compound over time. Users will typically find that 2-3 months or more of consistent Vyvamind use is far more effective than taking it infrequently. For best results and maximum effect we recommend continous use for 3 months or longer.

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